Superselective intracranial arterial thrombolysis with rt-PA, mechanical fragmentation and (or) solitairAB sent thrombectomy in patients with acute cerebral artery occlusion

Objective To study the clinical effects and safety of the treatment in acute cerebral artery occlusion with superselective intracranial arterial thromblysis by rt-PA,mechanical fragmentation by microcatheter and microguid wire and (or) solitairAB sent thrombectomy.Methods 42 patients of acute cerebral artery occlusion were treated by superselective intracranial arterial thrombolysis,mechanical fragmengation and (or) solitairAB sent thrombectomy from October 2010 to March 2012 and the data were retrospectively reviewed.Results Occluded arteries of 42 patients were dredged totally or partialy,the recanalization rate or partial recanalization rate of blocked blood vessel was 100％,including 37 cases with total recanalization (88％).After operation one case suffered from cerebral hemorrhage of basal ganglia,one subarachnoid hemorrhage,and one died of ardent fever after 8 days.9 cases (21％) remained functional impairments to some extents after medical therapy.The ranks of NIHSS between preoperation and 1 week after operation were discrepant obviously.Conclusions Superselective intracrainal arterial thrombolysis by rt-PA and papaverine,mechanical fragmentation by microcagheter and micoguide wire and (or) solitairAB sent thrombectomy in patients of acute cerebral artery occlusion is a safe and an effective therapy within the right time. Key words: Mechanical fragmentation ;  Sent thrombectomy;  Cerebrovascular occlusion ; Arterial thrombolysis