SYNTHESIS OF NOVEL PHENAZINE DERIVATIVES BY SOLID STATE CHEMISTRY AND PRELIMINARY SCREENING AGAINST PLASMODIUM FALCIPARUM IN VITRO .

Fourteen novel phenazines, together with seven known phenazinic derivatives were synthesized through solid state chemistry by reaction of �-lapachone and eight other o-quinones with four different ortho-diamines, and screened against Plasmodium falciparum in vitro . The pyrido-phenazine derivatives showed the greatest suppression of parasitic growth while the 1,2-dichloro-derivatives exhibited the least activity for a given ortho-diamine. With respect to the ortho-quinones, the phenazines obtained from �-lapachone gave the best results.