[Effect of surgery involving ovaries on the level of estradiol and gonadotropins in blood serum, with indications for hormonal treatment in early post-operative period being taken into consideration].

: The studies cover 124 women operated on at the Clinic of Operative Gynaecology IOG--PMA in Szczecin from 1981 to 1991. The blood for testing was collected prior to operation as well as in II and VIII 24-hours after the procedure. The material was divided into 5 groups: group I--31 patients, in whom one ovary or adnexa were removed in the first phase of cycle; group II--31 patients, whose uteri without adnexa were removed in the first phase of cycle; group III--31 post-menopausal patients, in whom uterus and adnexa were excised; group IV--comprised 31 post-menopausal patients, in whom uterus with adnexa was excised and subsequently estrogenic agents were given; group V--62 patients divided into subgroups A--16 patients with carcinoma of uterine cervix and ovary, and B--46 patients with neoplasm of uterine body. In all the patients FSH, LH, E2 were determined by RIA and EIA methods. The results were subjected to statistical analysis and elaborated by Student's t-test. The following has been disclosed: a) statistical significant diminution of E2 concentration with tendency to an increase in concentration of gonadotropins in the reproductive period after the excision of ovary and also uterus without adnexa; b) significant decrease in concentration of E2 and an increase of gonadotropins after excision of uterus with adnexa in patients operated on in the post-menopausal period, which supports the existence of ovarian steroidogenesis at this period of life. It has been disclosed that there was a significant rise in E2 concentration and a fall in concentration of gonadotropins following the application of Oestradiolum depot drug, which additionally confirms the activity of the hypothalamo-pituitary-ovarian system after menopause. A relation was found between the studied hormones and the basic disease, which also proves the function of hypothalamo-pituitary-ovarian system after menopause. The results of the studies fully substantiate the use of normal prophylaxis of consequences due to wavering of hypothalamo-pituitary-ovarian system in the reproductive period, as well as the metabolic consequences after menopause. They, however, fail to specify the period of time, at which the hormonal treatment may be applied best and most beneficially.