Abstract T P172: Temporal Correlation Perfusion Mapping Introduces a Robust and Rapid Method of Identifying Penumbra in Acute Ischemic Stroke

Background and Purpose: We implemented new temporal correlation perfusion (TCP) analyses that were rapid, model-free and automated. We assessed the reliability and robustness of TCP mapping compared to the standard method of time-to-peak (TTP) mapping used in the identification of perfusion deficit in acute ischemic stroke. Methods: A model-free and automated method of detecting aberrant perfusion was developed to create TCP maps based on the maximum temporal correlations of the signal time-intensity waveforms following contrast injection. For validation purposes, the TCP and TTP maps from IV tPA treated ischemic stroke (n=20) and untreated imaging negative TIA (n=20) patients were visually read for presence of perfusion deficit by two expert readers blinded to the clinical diagnosis. Next, the perfusion lesion volumes on the TCP and TTP maps were segmented by two other experts and were compared for inter-rater reliability, volumetric and spatial concordance, and contrast to noise ratio. Pearson’s r corre...