Increased CD1-positive cells in peripheral blood of AIDS and ARC patients

Abstract CD1 monoclonal antibodies were assayed on peripheral blood mononuclear leukocytes (PBML) of type 1 human immunodeficiency virus (HIV1)-infected patients using immunogold technique. Using IOT6 monoclonal antibody, a significant increase of the CD1 positive cells per μl of blood was found in acquired immunodeficiency syndrome (AIDS) and AIDS-related complex (ARC) patients (265 ± 34/ μ l, n = 44 and 491 ± 64/ μ l, n = 36, respectively) as compared to controls (108 ± 11/ μ l, n = 43, P