NEONATAL PIG ISLETS INDUCE A LOWER T-CELL RESPONSE THAN ADULT PIG ISLETS IN IDDM PATIENTS1

Background.Pancreatic pig islets may provide a substitute in the future for difficult to obtain human islets for transplantation in insulin-dependent diabetes millitus (IDDM) patients. However, the immune response to xenografts may significantly hamper this approach. Because neonatal tissue is belie