Zmiany w nerkach w zespole antyfosfolipidowym

Antiphospholipid syndrome (APS) is an autoimmune systemic disease characterized by recurrent venous and arterial thrombosis, obstetrical complications, and presence of antiphospholipid antibodies. Kidney in­volvement is not included in the APS diagnostic criteria, whereas in 10–40% of APS cases kidney vessels are affected. What is more, in catastrophic APS kidney in­volvement reaches 70%. APS is rarely detected at early stage of kidney involvement due to non-characteristic symptoms, that include changes in urine sediment and moderate hypertension. In this paper pathogenesis of APS nephropathy, and its clinical and pathologic mani­festations are discussed. Finally, current recommenda­tions in therapy and prophylaxis are presented.