A New Diphenylmethane Derivative from Uvaria kurizz with Cardiovascular Activity

Abstract Aim To study the chemical constituents of Uvaria kurzii (King) P. T. (Annonaceae). Method The chemical constituents were isolated with silica gel and Sephadex LH-20 column chromatography and their structures were elucidated by spectroscopic and synthetic methods. Results A diphenylmethane derivative ( 1 ) together with 5 known ent -kaurane diterpenoids ( 2–6 ) were isolated and identified as bis (4-octanoylphenyl) methane ( 1 ), ent -kaur-16-en-19-oic acid ( 2 ), grandifloric acid ( 3 ), ent -kaur-15-en-17-ol-19-oic acid ( 4 ), ent -16 α , 17-dihydroxykauran-19-oic acid ( 5 ) and ent -16β, 17-dihydroxykauran-19-oic acid ( 6 ). Conclusion Compound 1 was a new diphenylmethane derivative, and compounds 2–6 were isolated from the genus Uvaria for the first time. Bioactivity test on isolated rat heart failure model suggested 1 could increase coronary blood flow and myocardial contractive power compared with positive control ouabain.