Functional Neuroimaging of Cannabinoid Effects

Marijuana continues to be the most frequently abused illicit drug in America, despite modest declines from the height of its use in the mid-1970s. Approximately 70% of adults between the ages of 27 and 32 have used marijuana recreationally during their lifetime. Hollister (1) and Dornbush (2), respectively, showed that delta 9-tetrahydrocannabinol (THC), is the principal psycho-pharmacologically active component of marijuana, and its effects are dose and blood level dependent (3).