Effect of dibutyl phthalate on cognitive function in rats.

Objective:To observe the dibutyl phthalate(DBP)of newborn rat cognitive function.Methods:Forty 15-month-old mature male Wistar rats were divided into 4 groups(n=10),the control group(C group),DBP exposure group(E group),drug prevention group(P group),the drug treatment group(T group).Group E by eating foods DBP after soaking 3 months,P group consumed by DBP food after soaking three months,during the daily injection of microglial cell activation anti-drug indomethacin(in accordance with the 2.5mg/kg,2 times/day,intraperitoneal injection),T group consumed by DBP food after soaking three months after the use of indomethacin treatment(in accordance with the 2.5mg/kg,2 times/day,intraperitoneal injection of 1 week),C group were given the same dose of DBP. In 1d after stopping the use of Morris water maze test,the last water maze test rats were killed after 1h,check for chemical colorimetry hippocampus detected AChE activity in hippocampus.Results:E,P,T group and blank group,the ability of learning and memory in rats were significantly lower(P0.001),AChE activity increased significantly(P0.001);P、T group and E group,P group and T group compared to rats learning ability and memory capacity of no significant difference(P0.05),AChE activity was not significant(P0.05)). Conclusion:DBP can cause cognitive dysfunction in normal rats,the mechanism of rat hippocampus may be associated with an increase in the activity of AChE.