Polycyclic aryl and heteroaryl tertiary-heteroalquilamidas substituted as inhibitors of protein activity of cholesterol ester transfer.

A compound of formula DI, or a pharmaceutically acceptable salt thereof, wherein n is 1; R1 is haloalkyl; R2 is selected from the group consisting of hydrogen, alkyl, haloalkyl, aryl, and haloalkoxy; R3 is selected from the group consisting of hydrogen, alkyl and haloalkyl; Y is C1-2 alkylene; Z is a covalent bond; R4, R8, R9 and R13 are hydrogen or halo; R5, R6, R7, R10, R11 and R12 are independently selected from the group consisting of hydrogen, perhaloariloxi, N-aryl-N-alkylamino, heterocyclylalkoxy, heterocyclylthio, hydroxyalkoxy, arilalcanoiloxi, arylalkenyl, cycloalkylcarbonyl, cyanoalkoxy, heterocyclylcarbonyl, alkyl, halo , haloalkyl, haloalkoxy, aryl, alkylthio, arylamino, arylthio, aroyl, arylsulfonyl, aryloxy, arylalkoxy, heteroaryloxy, alkoxy, aralkyl, cycloalkoxy, cycloalkylalkoxy, cycloalkylalkanoyl, heteroaryl, cycloalkyl, haloalkylthio, hydroxyhaloalkyl, heteroarylalkoxy and heteroaryloxy.