Clinical and Laboratory Predictors of Dehydration Severity in Children with Diabetic Ketoacidosis

Objectives The degree of dehydration in children with diabetic ketoacidosis (DKA) is challenging to discern on presentation and its association with DKA outcomes is unclear. We aimed to characterize the degree of dehydration at presentation of DKA in a large cohort of children and to identify clinical and biochemical factors associated with severity of dehydration and outcomes. Methods This was a planned secondary analysis of data from the Pediatric Emergency Care Applied Research Network (PECARN) Fluid Therapies Under Investigation in DKA (FLUID) Study, a randomized clinical trial of fluid resuscitation protocols for children with DKA. Admission laboratory and physical examination data from …