Einfluss der sinusoidalen Architektur und der T-Zellimmunität auf metastatische Tumorzelladhäsion und -migration in vivo

The colonization of metastatic target organs by cancer cells requires tumor cell arrest in the microcirculation by specific adhesive interactions. In previous work we demonstrated integrin mediated tumor cell adhesion of human colon carcinoma cells within the hepatic sinusoids of male CD rats by in vivo fluorescent microscopy. Nevertheless immunologic interference in a xenogenic model and quantification of the rate of mechanical, size restricted cell arrest in the hepatic sinusoids remained elusive.