Development and Validation of Microbiological Analytical Method for Determination of Potency of Voriconazole Tablets

A new microbiological method was developed for analysis of voriconazole tablets using Candida albicans as test microorganism. Various media, species and conditions were used to optimize the diffusion test. A prospective validation of the system showed adequate linearity (0.995), accuracy (RSD Key words: Candida albicans, Comparison, Diffusion method, HPLC, Method validation, Voriconazole.