Hormonal mechanisms of peripheral neuropathy in vibration disease

Studies of peripheral limb nerves through stimulation electroneuromyography, evaluation of hormonal levels via radioimmune assay were performed in 59 patients having vibration disease caused by local vibration. Findings are obligatory signs of peripheral neuropathy and hypothyroid state without thyroid disease manifestations. Statistic analysis revealed reliable dependence between degree of motor axons functional deficit and level of serum triiodothyronine and thyroxin decrease--that could point to participation of thyroid hormones in peripheral neuropathy progression in vibration disease.