The method of producing a purified erythromycin thiocyanate

The present invention provides a method for purifying erythromycin thiocyanate. A method for purification of erythromycin thiocyanate, including (1) erythromycin bleaching filtrate and washings preliminary coagulant to the complex, obtained was extracted with erythromycin special solvent after decontamination liquid, to extract decolorized with charcoal further dedoping. (2) erythromycin extracts were treated with purified water to a phase inversion, and then the aqueous phase was extracted to erythromycin butyl acetate, a mixed solvent of cyclohexane, two-step crystallization process to obtain Erythromycin liquid crystal element, separated and dried to give erythromycin thiocyanate finished. Erythromycin A content of the finished product 83%. The present invention is extracted from erythromycin for erythromycin in the filtrate using the traditional production process special solvent, and then crystallized from the extract and finally isolated and dried to give the final product of erythromycin thiocyanate low content of erythromycin A disadvantage of filtrate and the washings and extracts were decolorized to the complex, after transfection with the two-step method of crystallization, increased content of the finished product of erythromycin a erythromycin thiocyanate.