Thickness of macular inner retinal layers and peripapillary retinal nerve fibre layer in neuromyelitis optica spectrum optic neuritis and isolated optic neuritis with one episode

Purpose The aim of this study was to evaluate the differences between macular inner retinal layers and peripapillary retinal nerve fibre layer (pRNFL) thickness in Chinese patients with neuromyelitis spectrum optic neuritis (NMOSD-ON) and isolated optic neuritis (ION) with only one episode. Methods This cross-sectional study included 35 patients (35 eyes) with NMOSD-ON (NMO-IgG seropositive) and 46 patients (46 eyes) with ION after one episode. Spectral domain optical coherence tomography (SD-OCT) was used to quantify pRNFL, macular RNFL (mRNFL), ganglion cell and inner plexiform layers (GCIPL) and inner nuclear layer (INL) thickness using an automated algorithm. Differences in OCT parameters between NMOSD-ON and ION were compared after adjusting for age, sex and disease duration. Results The pRNFL and mRNFL in some locations (average pRNFL, nasal pRNFL, nasal inferior (NI) pRNFL, nasal/temporal (N/T) ratio pRNFL, average mRNFL, inner temporal mRNFL, outer nasal mRNFL and outer temporal mRNFL) in NMOSD-ON differed significantly from those in ION (all p   0.05). This study and our meta-analysis of four previous studies obtained consistent results, with pooled mean difference (MD) −10.4 μm (95% CI: −12.4 to −8.4, p < 0.001) for pRNFL, −1.5 μm (95% CI: −3.5 to 0.6, p = 0.158) for mRNFL and 0.2 μm (95% CI: −0.4 to 0.9, p = 0.490) for GC-IPL, respectively. Conclusions Neuromyelitis spectrum optic neuritis (NMOSD-ON) patients had more pRNFL and mRNFL loss compared to ION patients after one episode. Spectral domain optical coherence tomography (SD-OCT) may help to distinguish NMOSD-ON from ION with only moderate diagnostic accuracy.