Early local drug therapy for pancreatic contusion and laceration

Abstract Objectives To study the therapeutic effect of early local drug therapy on pancreatic contusion and laceration. Methods Twenty pigs were divided into 4 groups: model(PL), 1 ml of saline; medical protein glue (EC), 1 ml of medical protein glue; ulinastatin (UL), 50000U of ulinastatin; combined treatment (UE), 1 ml of medical protein glue and 50000U of ulinastatin. 30 min after model establishment, different groups received different local drug treatments. The pancreatic function, peritoneal effusion and pancreatic pathology were observed. Results The UE group got the best therapeutic effect. The changes of pancreatic function and the peritoneal effusion were compared with PL group as follows. 0-6h: amylase (p   0.05), effusion (p   0.05), lipase (p  Conclusions Early local drug therapy in pancreatic contusion and laceration could effectively control the development of the disease and improve the prognosis.