Determination of lincomycin hydrochloride in lincomycin cream by HPLC
2008
Objective:To establish high performance liquid chromatography method for determination the content of lincomycin hydrochloride in lincomycin cream.Methods:A YMC C18(250 mm×4.6 mm,5μm)column was used with the mobile phase of 0.05mol/L borax (adjust pH to 6.0 with phosphoric acid)-methanol (55:45)and UV wavelengh of 214 nm.Results:The calibration curve of lincomycin hydrochloride was line in the range of 10~30μg(r=0.999 7).The average recovery was 98.74%(RSD= 2.06%,n=9).The relative content of lincomycin hydrochloride in three batch of lincomycin cream was 96.21%,96.50% and 93.38%.Conclusion:This method is simple,quick,accurate and suitable for the quality control of lincomyein cream.
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