Transcription errors induce proteotoxic stress and shorten cellular lifespan
2015
Transcription, like DNA replication, is an error-prone process. Vermulst et al. show that transcription errors increase with age in yeast, and find that prematurely increasing the error rate overwhelms the proteotoxic stress response, allowing aggregation-prone proteins to escape protein quality control.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
49
References
49
Citations
NaN
KQI