Puva Therapy and Isotretinoin in the Treatment of Patients with Follicular Dyskeratosis Darier

The paper presents data on the use of retinoid isotretinoin in the dose of 10mg in combination with PUVA therapy in treatment of patients with Darier's diseas. This combined method has a high therapeutic efficacy and this confirms the dynamics of the index of dermatological status and quality of life. This method has a preventive value and is accompanied by an increase of the remission. High safety of combined pharmacological and physiotherapeutic method is demonstrated.