A Short, Convergent Synthesis of Two Chiral Antiviral Agents, (+)- Carbocyclic 2′-Deoxy-5-((E)-2-Bromovinyl) Uridine and (+)-Carbocyclic 2′-Deoxyguanosine.

Stereoselective microbial reduction of ketone 2 gave the alcohol 5 which was coupled under Mitsunobu conditions with the protected pyrimidine 7 and purine 10 to give on deprotection the chiral antiviral nucleosides (+) carbocyclic 2′-deoxy-5-[(E)-2bromovinyll uridine 9 and (+) carbocyclic 2′-deoxyguanosine 12.