Toward a high-throughput screening platform for directed evolution of enzymes that activate genotoxic prodrugs

J.N.Copp1,2,5, E.M.Williams1,2, M.H.Rich1,2, A.V.Patterson3,4, J.B.Smaill3,4 and D.F. Ackerley1,2,3,6 School of Biological Sciences, Victoria University of Wellington, Wellington 6012, New Zealand, Centre for Biodiscovery, Victoria University of Wellington, Wellington 6012, New Zealand, Maurice Wilkins Centre for Molecular Biodiscovery, School of Biological Sciences, University of Auckland, Auckland 1010, New Zealand, Auckland Cancer Society Research Centre, University of Auckland, Grafton, Auckland 1023, New Zealand and Present address: Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada