A General Kilogram Scale Protocol for Suzuki–MiyauraCross-Coupling in Water with TPGS-750‑M Surfactant

Michael Parmentier,Mona K. Wagner,Regina Wickendick,Markus Baenziger,Audrey Langlois,Fabrice Gallou

A General Kilogram Scale Protocol for Suzuki–MiyauraCross-Coupling in Water with TPGS-750‑M Surfactant

2020

Michael Parmentier
Mona K. Wagner
Regina Wickendick
Markus Baenziger
Audrey Langlois
Fabrice Gallou

The development of a kilogram scale protocol for a Suzuki-Miyaura cross-coupling step towards the synthe-sis of the drug candidate LSZ102 is described. Particularly, the use of the surfactant TPGS-...

Keywords:

Pulmonary surfactant
Kilogram
Halogenation
Chemistry
Chemical engineering
drug candidate
Selectivity
Inorganic chemistry
Coupling

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