Regenerative Approaches in Orthodontic and Orthopedic Treatment

In this chapter, we will introduce the concept of regenerative approaches in orthodontic and orthopedic treatments. We will specifically focus on the current tissue engineering approaches in bone/cartilage remodeling, which could be stem cell based, biomaterial based, or a combination. We will then discuss the potential applications of bone/cartilage engineering technologies to address clinical problems, including jaw discrepancies, bone loss due to periodontal diseases, and temporomandibular disorders. In each disease model settings, the current evidence (preclinical/clinical) in applying the regenerative approaches will be discussed and the foreseeable opportunities and challenges will be addressed. Finally, a summary of the main findings and future directions will be provided.