Case 7-1995

Presentation of Case A 58-year-old man with common variable immunodeficiency, recurrent sinusitis, splenomegaly, and mild thrombocytopenia was admitted to the hospital because of severe anemia and jaundice. He had a 10-year history of recurrent sinusitis, which responded to treatment with various antibiotics. Laboratory studies eight years before admission had led to a diagnosis of common variable immunodeficiency (Table 1). The patient received immune globulin intravenously and was given frequent courses of antibiotics to suppress bouts of acute sinusitis. Thirty-eight months before admission radiographs of the abdomen revealed splenomegaly. During the next three years the platelet count gradually declined from 280,000 . . .