SYNTHESIS, ENZYMATIC PHOSPHORYLATION AND ANTIVIRAL ACTIVITY OF ACYCLIC DIENYL PHOSPHONATE DERIVATIVES OF GUANINE
1996
Abstract The synthesis, phosphorylation by guanylate kinase, anti HIV-1 and anti-herpesvirus activity of two acyclic dienyl phosphonate derivatives of guanine are described. (E)-9-(5-phosphono-3-methylene-4-pentenyl)guanine ( 4 ) was identified as an excellent substrate of guanylate kinase and a significant inhibitor of HIV-1 replication.
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