Immunological Studies for Using of Combined Inactivated Respiratory Virus Vaccine (Pneumo-3) and Sheep Pox Vaccine in Goats

This study was conducted for explaining the use of combined inactivated pneumo-3 vaccine (bovine viral diarrhea, bovine herpes virus -1 and parainfleunza-3 viruses) as a diluent for sheep pox virus vaccine to be used as a vaccine for goats in one shot. 16 balady adults' male goats were used which were seronegative against each virus used in this study. All goats were randomly divided into four groups each one consists of four goats. The first group was vaccinated against sheep pox using sheep pox vaccine (Veterinary Serum and Vaccine Research Institute, Cairo) subcutaneously (s/c). While the second group vaccinated with pneumo-3 vaccine (Veterinary Serum and Vaccine Research Institute, Cairo) in two doses with two weeks apart by 3ml s/c. The third group was vaccinated with the pneumo-3 and sheep pox vaccines as one mixture in one shot s/c. The fourth group was left as non-vaccinated control group. Serological investigation using SNT and ELISA revealed that there was no competition or interaction between each fraction of both vaccines but in contrast the results obtained revealed that the immune response induced by vaccination of the mixture prepared from both vaccines gave elevated and higher immunity than that of the second group. In conclusion, using of sheep pox and pneumo-3 mixture vaccines could be used safely as one shot vaccine and is recommended to be used in the field for protection of goats against such infections.