AN IMPROVED SYNTHESIS OF N-[(9-HYDROXYMETHYL)-2-FLUORENYL]SUCCINAMIC ACID (HMFS), A VERSATILE HANDLE FOR THE SOLID-PHASE SYNTHESIS OF BIOMOLECULES

Fernando Albericio,Montse Cruz,Laurent Debéthune,Ramon Eritja,Ernest Giralt,Anna Grandas,Vicente Marchán,Jose J. Pastor,Enrique Pedroso,Francesc Rabanal,Miriam Royo

AN IMPROVED SYNTHESIS OF N-[(9-HYDROXYMETHYL)-2-FLUORENYL]SUCCINAMIC ACID (HMFS), A VERSATILE HANDLE FOR THE SOLID-PHASE SYNTHESIS OF BIOMOLECULES

2001

Fernando Albericio
Montse Cruz
Laurent Debéthune
Ramon Eritja
Ernest Giralt
Anna Grandas
Vicente Marchán
Jose J. Pastor
Enrique Pedroso
Francesc Rabanal
Miriam Royo

The optimization of a synthetic process for the preparation of HMFS handle, which is used for the solid-phase synthesis of peptides and oligonucleotides, is presented.

Keywords:

Organic chemistry
Combinatorial chemistry
Biomolecule
Oligonucleotide
Chemistry
Solid-phase synthesis
Hydroxymethyl

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