С-реактивный белок при подагрическом артрите: связь с кардиоваскулярной патологией

Objective. To study relationship between hs-CRP concentration and cardiovascular pathology in pts with gout. Material and methods. 161 pts with gout fulfilled the Wallace S. criteria were included. Mean age was 50,9±11,6 years, mean disease duration 5,6 (2,9-11,0) years. Summated coronary risk (SCR) was estimated according to recommendations elaborated for Russian population. Serum CRP concentration was assessed by high-sensitivity (hs) immunoenzyme assay with commercial kits of "Biometrica" (USA). Pts were examined in the absence of active gout arthritis. Results. Serum hs-CRP level in gout pts was 12,7 (5,8-19,0) mg/1. All pts were divided into two groups. Group 1 included 82 pts (hs-CRP > 12,7 mg/1), group 2-79 pts (hs-CRP> 12,7 mg/1). The pts of group 2 had longer disease duration and more damaged joints during the disease. Pts with SCR>20% had higher hs-CRP level 13,7 (7,6-21,3) mg/l than pts with SCR