PERITONITIS AMONG CAPD PATIENTS: HOST, AGENT AND/OR ENVIRONMENT?

The invention refers to pharmaceutical compositions suitable for the protection of the mitochondrial genom and/or mitochondrium from damages or for the treatment of diseases connected with such damages, said compositions comprising a hydroximic acid derivative of the formula:whereinR1 represents a hydrogen or a C1-5 alkyl group,R2 stands for a hydrogen, a C1-5 alkyl group, a C3-8 cycloalkyl group or a phenyl group optionally substituted by a hydroxy or a phenyl group, orR1 or R2 together with the nitrogen atom they are attached to form a 5 to 8 membered ring optionally containing one or more further nitrogen, oxygen or sulfur atom(s) and said ring can be condensed with another alicyclic or heterocyclic ring, preferably a benzene, naphthalene, quinoline, isoquinoline, pyridine or pyrazoline ring, furthermore, if desired and chemically possible, the nitrogen and/or sulfur heteroatom(s) are present in the form of an oxide or dioxide,R3 means a hydrogen, a phenyl group, a naphthyl group or a pyridyl group wherein said groups can be substituted by one or more halo atom(s) or C1-4 alkoxy group(s),Y is a hydrogen, a hydroxy group, a C1-24 alkoxy group optionally substituted by an amino group, a C2-24 polyalkenyl-oxy group containing 1 to 6 double bond(s), a C1-25 alkanoyl group, C3-9 alkenoyl group or a group of the formula R7-COO-, wherein R7 represents a C2-30 polyalkenyl group containing 1 to 6 double bond(s),X stands for a halo, an amino group, a C1-4 alkoxy group, orX forms with B an oxygen atom, orX and Y together with the carbon atoms they are attached to and the -NR-O-CH2 group being between said carbon atoms form a ring of the formulawhereinZ represents an oxygen or a nitrogen,R stands for a hydrogen orR forms with B a chemical bond,A is a C1-4 alkylene group or a chemical bond or a group of the formulawhereinR4 represents a hydrogen, a C1-5 alkyl group, a C3-8 cycloalkyl group or a phenyl group optionally substituted by a halo, a C1-4 alkoxy group or a C1-5 alkyl group,R5 stands for a hydrogen, a C1-4 alkyl group or a phenyl group,m has a value of 0, 1 or 2,n has a value of 0, 1 or 2,or a pharmaceutically acceptable acid addition salt thereof as the active ingredient.