Synthesis of nedocromil sodium

Objective This study aims at developing a new method to synthesize nedocromil sodium. Methods In this experiment,3-methoxyaniline was taken as the raw material,nedocromil sodium was obtained after a series of chemical reactions including acylation,Friedel-Crafts reaction,Claisen rearrangement,and esterification. Results The six-step synthesis is simple to operate and easy to control conditions,and yield high. Conclusion It is a desirable method for the synthesis of nedocromil sodium.