Clinical/Translational Research Whole Body UVA Irradiation Lowers Systemic Blood Pressure by Release of Nitric Oxide From Intracutaneous Photolabile Nitric Oxide Derivates

species, as detected by a chemiluminescence assay, with increased forearm blood flow (267%), with increased flow mediated vasodilation of the brachial artery (6822%), and with decreased forearm vascular resistance (287%). Conclusions: UVA irradiation of human skin caused a significant drop in blood pressure even at moderate UVA doses. The effects were attributed to UVA induced release of NO from cutaneous photolabile NO derivates. (Circ Res. 2009;105:1031-1040.)