Access Site Complications of Postcardiotomy Extracorporeal Life Support

Abstract Objective To assess the impact of primary arterial access in patients receiving peripheral postcardiotomy extracorporeal life support (PC-ECLS) on associated complications and outcome. Methods Of 573 consecutive patients requiring PC-ECLS between 2000-2019 at a single center, 436 were included in a retrospective analysis and grouped according to primary arterial ECLS-access site. Survival and rate of access-site related complications with special emphasis on fatal/disabling stroke were compared. Results The axillary artery was cannulated in 250 patients (57.3%) while the femoral artery was used as primary arterial access in 186 patients (42.6%). There was no significant difference in 30-day (ax: 62%; fem: 64.7%; p=0.561) and 1-year survival (ax: 42.5%; fem: 44.8%; p=0.657). Cerebral computed tomography-confirmed stroke with a modified ranking scale (MRS) ≥4 was significantly more frequent in the axillary group (ax: n=28, 11.2%; fem: n=4, 2.2%; p=0.0003). Stroke localization was right hemispheric (n=20; 62.5%); left hemispheric (n=5, 15.6%), bilateral (n=5; 15.6%), or infratentorial (n=2; 6.25%). While no difference in major cannulation site bleeding was observed, cannulation site change for bleeding was more frequent in the ax group (ax: n=13; 5.2%; fem: n=2; 1.1%; p=0.03). Clinically apparent limb ischemia was significantly more frequent in the femoral group (ax: n=12, 4.8%; fem: n=31, 16.7%; p Conclusions Although survival did not differ, surgeons should be aware of access-site specific complications when choosing peripheral PC-ECLS access. While lower rates of limb ischemia and the advantage of antegrade flow seem beneficial for axillary cannulation, especially the high incidence of right hemispheric strokes in axillary artery cannulation should be considered.