Generic ion chromatography-conductivity detection method for analysis of palladium scavengers in new drug substances

The revolution of palladium-catalyzed reactions in the synthesis of new molecules has created an unprecedented need for highly efficient palladium (Pd) removal processes. Metal scavengers with very selective and efficient removal properties are being extensively applied across process research & development (PRD however, developing methodologies to detect a variety of Pd-scavengers in multicomponent reaction mixtures is currently considered an emerging challenge in pharmaceutical analysis. Herein, a simple and efficient generic ion chromatography-conductivity detection (IC-CD) method on a Dionex IonPac AS19 column in conjunction with a fully aqueous eluent profile (potassium hydroxide-based) capable of chromatographically resolving over 10 Pd-scavenger species commonly used in PR&D workflows is described. Computer-assisted separation modeling using ACD Labs/LC Simula...