Nonsteroidal Antinflammatory Drug and Alzheimer Disease

Neuroinflammation is one of the causes of neuronal injury in the pathogenesis of Alzheimer’sdisease (AD). Epidemiological studies suggest that nonsteroidal anti-inflammatory drugs (NSAID) reduce therisk of AD. Laboratory evidence indicates that the protection of NSAID is mediated by inhibition ofcyclooxygenase (COX) activity and the non-COX mechanisms. However, there is not yet any strong evidencefrom large randomized controlled clinical trials that NSAID is beneficial in treatment to AD. This reviewsummarizes the experimental, epidemiological and clinical studies concerning NSAID and AD.