Comparison of Recovery Criteria Following Anaesthesia with Sevoflurane and Isoflurane in Geriatric Patients

Objectives: The aim of this study was to compare the effects of volatile anesthetics, sevoflurane and isoflurane, on recovery criteria in geriatric patients. Study Design: Forty ASA I-II patients at the age of 65 years or above, who were planned for elective urological or gynecological operation were randomized to two groups equal in number. Each group received 0.06 mgkg-1 intramuscular midazolam for premedication, and intravenous 1.5 mgkg-1 propofol, 0.6 mgkg-1 atracurium besylate, and 500 amicro;g alfentanil for induction. Anesthesia was maintained with approximately 1 MAC isoflurane in group I, and 1 MAC sevoflurane in group II, and, when necessary, intravenous 0.1 mgkg-1 atracurium. Recovery criteria included spontaneous eye opening, extubation, verbal response, and orientation times at the end of operation. Results: Compared to the isoflurane group, durations of spontaneous eye opening (p=0.0002), extubation (p=0.0002), verbal response (p=0.0001), and orientation (p=0.0001) were significantly shorter in the sevoflurane group. Conclusion: We concluded that sevoflurane anesthesia is more advantegous over isoflurane in geriatric patients. Turkish Baslik: Geriyatrik Hastalarda Sevofluran ve Isofluranin Derlenme Kriterleri Uzerine Etkilerinin Karsilastirilmasi Anahtar Kelimeler: Yaslilik; anestezi, derlenme donemi; anestetik, inhalasyon; isofluran/farmakoloji/ilac etkisi; sevofluran/farmakoloji/ ilac etkisi Amac: Bu calismada, geriyatrik hastalarda volatil anesteziklerden sevofluran ve isofluranin derlenme kriterleri uzerine etkileri karsilastirildi. Calisma Plani: Elektif urolojik ve jinekolojik cerrahi girisim planlanan ASA I-II grubundan 65 yas ve uzeri 40 hasta rastgele esit sayida iki gruba ayrildi. Tum olgularin premedikasyonu intramuskuler 0.06 Mgkg-1 midazolam, anestezi induksiyonu intravenoz 1.5 mgkg-1 propofol, 0.6 mgkg-1 atrakuryum besilat ve 500 amicro;g alfentanil ile gerceklestirildi. Anestezi idamesi grup Ia#39;de 1 MAC isofluran, grup IIa#39;de 1 MAC sevofluran ve gerektikce intravenoz 0.1 Mgkg-1 atrakurium ile surduruldu. Ameliyat sonunda her iki grupta da derlenme kriterleri olarak belirlenen spontan goz acma, ekstubasyon, sozel yanit ve oryantasyon sureleri kaydedildi. Bulgular: Sevofluran grubunda, isofluran grubuna gore spontan goz acma (p=0.0002), ekstubasyon (p=0.0002), sozel yanit (p=0.0001) ve oryantasyon (p=0.0001) sureleri anlamli derecede kisa bulundu. Sonuc: Geriyatrik olgularda sevofluranin derlenme kriterleri acisindan isoflurana gore daha avantajli oldugu kanisina varildi.