Facile Synthesis of a Series of Non-Symmetric Thioethers Including a Benzothiazole Moiety and Their Use as Efficient In Vitro anti-Trypanosoma cruzi Agents

Alcives Avila-Sorrosa,Jazz D. Tapia-Alvarado,Benjamín Nogueda Torres,Karla Fabiola Chacón-Vargas,Francisco Díaz Cedillo,María Elena Vargas-Díaz,David Morales-Morales

Facile Synthesis of a Series of Non-Symmetric Thioethers Including a Benzothiazole Moiety and Their Use as Efficient In Vitro anti-Trypanosoma cruzi Agents

2019

Alcives Avila-Sorrosa
Jazz D. Tapia-Alvarado
Benjamín Nogueda Torres
Karla Fabiola Chacón-Vargas
Francisco Díaz Cedillo
María Elena Vargas-Díaz
David Morales-Morales

A series of 2-benzylsulfanyl benzothiazole (BTA) derivatives were synthesized and fully characterized and in vitro tested against two strains of T. cruzi (NINOA and INC-5), exhibiting good activities at low concentrations.

Keywords:

Chagas disease
Moiety
Stereochemistry
Organic chemistry
Trypanosoma cruzi
Chemistry
In vitro
Benzothiazole
non symmetric
volume concentration

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