Olanzapine orally disintegrating tablet and preparation method thereof

2013 
The invention relates to an olanzapine orally disintegrating tablet and a preparation method thereof. The orally disintegrating tablet has a disintegration time limit of less than or equal to 10 seconds, and comprises: a) 2%-15% of olanzapine by weight; b) 20%-78% of mannitol by weight; c) 10%-40% of microcrystalline cellulose by weight; d) 1%-20% of crosslinked povidone by weight; e) 0.2%-5% of aspartame by weight; and f) 0.3%-4% of magnesium stearate by weight. From the perspective of whole effect, the olanzapine orally disintegrating tablet provided by the invention has the characteristics of fast disintegration speed, simple technological steps, low cost, and convenient oral administration, thus being suitable for wide promotion and application.
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