Research status of rhoptry protein of Toxoplasma gondii and its nucleic acid vaccine

: At present, there are no ideal drugs and measures in the treatment and prevention of toxoplasmosis. The development of safe, convenient, and strong protective nucleic acid vaccine is an important strategy for prevention and control of toxoplasmosis. The rhoptry protein (ROP) is a large class of proteins secreted by Toxoplasma gondii. ROPs play an important role in the invasion of host cells, the formation of parsitophorous vacuole (PV) and the regulation of proliferation by T. gondii. Thus, ROPs become the most promising candidates of vaccine. In this paper, we summarize the important members of the ROPs, the expression vector and the immunogenicity and immunoprotection of the nucleic acid vaccine in animal experiments.