Complement drives glucosylceramide accumulation and tissue inflammation in Gaucher disease

Manoj K. Pandey,Thomas A. Burrow,Reena Rani,Lisa J. Martin,David P. Witte,Kenneth D. R. Setchell,Mary McKay,Albert F. Magnusen,Wujuan Zhang,Benjamin Liou,Jörg Köhl,Gregory A. Grabowski

Complement drives glucosylceramide accumulation and tissue inflammation in Gaucher disease

2017

Manoj K. Pandey
Thomas A. Burrow
Reena Rani
Lisa J. Martin
David P. Witte
Kenneth D. R. Setchell
Mary McKay
Albert F. Magnusen
Wujuan Zhang
Benjamin Liou
Jörg Köhl
Gregory A. Grabowski

Complement-activating glycosylceramide-specific autoantibodies drive a self-propagating cycle of glycosylceramide accumulation and inflammation in Gaucher disease.

Keywords:

Autoantibody
Inflammation
Immunology
Disease
Complement system
Biology
Proinflammatory cytokine
Immune system
Ceramide glucosyltransferase
C5a receptor
Complement C5a
Glucocerebrosidase

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