Het ontregelde brein; consequenties van ruimtelijke en temporele complexiteit van het brein voor pathofysiologie en diagnostiek van de bipolaire stoornis. The dysregulated brain - Consequences of spatial and temporal brain complexity for bipolar disorder pathophysiology and diagnosis.
2018
markdownabstractBACKGROUND Despite the existence of several pathophysiological theories about bipolar disorder, it has so far been
difficult to find diagnostic biomarkers and to develop new pharmacologic treatments based on the
more novel theories.
AIM To reflect on the causes and consequences of problems that beset pathophysiological research into
psychiatric disorders in general and bipolar disorder in particular.
METHOD In this essay we address the problems facing professionals engaged in research into bipolar disorder
and we interpret these problem in the light of brain complexity.
RESULTS The complexity of the brain can be divided into two types: spatial complexity, which reflects the various
physiological levels of the central nervous system (genetic, molecular, cellular, neuronal circuits
and phenomenological levels), and temporal complexity, i.e. neurodevelopment. We discuss the
consequences of these two types of complexity and make suggestions relating to clinical practice
and pathophysiological psychiatric research.
CONCLUSION To achieve further progress in the field of brain research, we need to acquire a deeper understanding
of the spatial and temporal complexity of the brain and consider the possible consequences of such
knowledge for the pathophysiology and treatment of psychiatric illnesses such as bipolar disorder.
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