Thiazoles and thiopyridines: novel series of high affinity h5HT7 ligands

A series of thiazole based 5HT7 ligands has been identified from screening. Optimisation of the pendent aryl group and modification of the core gave a related series of high affinity, selective thiopyridine based 5HT7 ligands, the most active of which behaves as a partial agonist.