The Presence of Essential and Non-Essential Stratum Corneum Proteases: The Vital Need for Protease Inhibitors
2017
Dry skin is one of the most important
concerns of consumers worldwide.
Despite huge efforts over several decades,
the personal care industry still
does not offer complete solutions that
satisfy the unmet needs of consumers
for moisturizing treatments. The
paucity of data for the underlying biochemical
problems in and the effects
of moisturizers on facial skin biology
and physiology may partly explain
this. Our recent color mapping studies
based on bio-instrumental evaluations
of skin capacitance and transepidermal
water loss have revealed the
complexity of facial skin. However,
the biomolecular reasons for these
subtle differences in the different
zones of the face are unknown so
far. As the maturation of the stratum
corneum is vital for skin moisturization
and optimal barrier function, we
believe that the protease / proteaseinhibitor
balance particularly of the
plasminogen system may be key in
these processes. Thus, our aim was
to develop a specific dual plasmin and
urokinase inhibitor for topical application
to barrier-impaired skin and
demonstrate its efficacy
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