DRUG SYNTHESIS METHODS AND MANUFACTURING TECHNOLOGY CHEMICAL PROPERTIES AND IMMUNOTROPIC ACTIVITY OF THE PRODUCTS FROM REACTION OF N-(6-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDRO-5H- PYRIMIDINESULFONE)-N-ISONICOTINOYLHYDRAZIDE WITH ACIDS AND BASES IN AQUEOUS MEDIA

The effect of tautomerism on the structure of products from the reaction of N-(6-methyl-2,4-dioxo-1,2,3,4tetrahydro-5H-pyrimidinesulfone)-N -isonicotinoylhydrazide (kristafon) with acids (hydrochloric, phosphoric, acetic, oxalic, succinic, citric, hyaluronic) and bases [sodium hydroxide, triethanolamine, tris-(hydroxymethyl)aminomethane] in aqueous media has been studied using UV, IR, PMR, and 13 C NMR spectroscopy techniques. The properties of kristafon are compared to those of analogous compounds containing pyridine (isonicotine hydrazide, sulfotolylisonicotine hydrazide) and pyrimidine [bis-p-(2,4-dioxo-6-methylpyrimidinyl-5-sulfonamino)-diphenylsulfone] fragments in acid–base media. It is shown that the immunotropic activity of kristafon phosphate and kristafon are improved in hyaluronic acid solution.