[Effect of ethyl alcohol on bile production and lipid peroxidation in tetracycline-induced liver lesions].

The experiments with male albino rats showed that in toxic doses tetracycline induced affections of the liver evident from activation of transferases and alkaline phosphatases in the blood serum, inhibition of bile secretion, synthesis and secretion of bile acids and excretion of bilirubin and cholesterol with the bile. Moreover, the content of the products of lipid peroxidation in liver homogenates increased. Acute intoxication with ethyl alcohol also induced hepatic disorders. However, they were less pronounced. The intoxication was accompanied by inhibition of cholopoiesis associated with increasing free radical oxidation of lipids. On combined use of tetracycline and ethyl alcohol no potentiation or summation of their hepatotoxicity was observed.