Interaction between cellular and serum factors of immunity in the course of chemical carcinogenesis

The effect of serum components on manifestation of the cellular reactions of immunity during chemical carcinogenesis was investigated by studying inhibition of migration of peritoneal macrophages from the capillaries. The level of inhibition of migration of the macrophages was higher and inhibition was observed in a larger percentage of cases when macrophages were cultured on autologous serum of animals with induced tumors than when normal sera were added to this test system. In cases in which the ability of the macrophages to migrate was increased, the serum of normal animals facilitated this phenomenon more than the serum of rats with induced carcinogenesis. The cellular reactions of immunity were sharply reduced at the 6th month of carcinogenesis regardless of the action of serum factors.