Karatungiols A and B, Two Novel Antimicrobial Polyol Compounds, from the Symbiotic Marine Dinoflagellate Amphidinium sp.

Abstract Karatungiols A ( 1 ) and B ( 2 ), two novel antimicrobial polyol compounds, were isolated from the cultivated symbiotic marine dinoflagellate Amphidinium sp. Their structures were elucidated based on spectroscopic analysis and degradation reactions. Karatungiols A ( 1 ) and B ( 2 ) consisted of a C69-linear chain with a ketone moiety, 24 or 25 hydroxyl groups, and two tetrahydropyran rings. Karatungiol A ( 1 ) exhibited antifungal activity against Aspergillus niger at 12 μg/disc and antiprotozoan activity against Trichomonas foetus at 1 μg/ml.