Measurement of acetaldehyde in exhaled breath using a laser absorption spectrometer
2007
A high-resolution liquid-nitrogen-free mid-infrared tunable diode laser absorption spectroscopy (TDLAS) system was used to perform real-time measurement of
acetaldehyde concentrations in human exhaled breath following ingestion of an alcoholic
beverage. Acetaldehyde absorption features were measured near
5.79 μm (1727 cm−1)
using a IV-VI semiconductor laser, a
100 m long path optical gas cell, and second-
harmonic detection coupled with wavelength modulation. Acetaldehyde levels were
measured with a minimum detection limit of 80 ppb for 5 s integration time.
The variations in exhaled acetaldehyde levels over time were analyzed prior to and following
ingestion of two different amounts of white wine. A method to calibrate acetaldehyde
measurements internally using water vapor absorption lines was investigated to eliminate
the need for system calibration with gas standards. The potential
of a TDLAS system to be used as a noninvasive clinical tool for measurements of large
volatile compounds with possible applications in cancer detection is demonstrated.
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