Impact of prophylactic bilateral salpingo-oophorectomy on bone health in BRCA mutation carriers: A prospective cohort study.

1566Background: Women who inherit a deleterious mutation in BRCA1 or BRCA2 face a high lifetime risk of ovarian cancer. Prophylactic bilateral-salpingo oophorectomy (PBSO) is recommended prior to natural menopause; however, the impact of abrupt hormonal withdrawal on bone health in this high-risk population is not known. We conducted a longitudinal study to evaluate the impact of PBSO on bone mineral density (BMD) in BRCA mutation carriers. Methods: The study population included women who underwent PBSO at the University Health Network (Toronto, Canada) between January 2000 and May 2013. Eligibility criteria included having a BRCA mutation, at least one ovary prior to surgery, and no personal cancer history other than breast cancer. Information regarding medical history, medication use, and lifestyle factors was collected via questionnaire. BMD measurements using dual x-ray absorptiometry were collected at baseline (prior to surgery) and follow-up. The % change in BMD from baseline to follow-up was calcul...